Dr. Speranza grew up in New Jersey. She is named after her maternal grandmother. She is a graduate of Oberlin College where she studied performance oboe and neuroscience. She then attended Albert Einstein College of Medicine and moved to Connecticut to do her residency at Yale New Haven Hospital. She has been named by Connecticut Magazine as one of "Connecticut's Top Doctors" every year since 2013. She lives in New Haven with her husband and two children.